
Holier-than-thou
Goody-goody / Do-gooder / To be all virtue and piety / A sly one / Goody two-shoes

Santarellina 
Goody-goody / Do-gooder / To be all virtue and piety / A sly one / Goody two-shoes

Santarellina 
Meanings
To act as if morally better than other people
Examples
Don't give me that holier-than-thou look, I know you did it
Non fare quell'aria da santarellina, so benissimo che sei stata tu
She looks like a goody-goody, but you should see her at parties after a couple of drinks. So much for still water…!
Fa tanto la santarellina, ma dovresti vederla alle feste dopo un paio di bicchierini. Altro che acqua cheta…!
She would play it like she is all virtue and piety, bur she's not! Believe me, I know her very well
Vuol apparire come una santarellina, ma non lo è! Credimi, io la conosco molto bene